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Mineral and Bone Disease

Among the several body systems affected by kidney disease, mineral and bone disease is an important one. As chronic kidney disease progresses, abnormalities in calcium, phosphorus, vitamin D metabolism, and other hormone issues can be expected.

How does kidney disease lead to bone disease? 


CKD leads to a decrease in conversion of vitamin D into its active form. In addition, phosphorus is unable to be removed from the body by the kidneys. These changes result in an overproduction of parathyroid hormone, which normally helps to regulate bone health. This is referred to as secondary hyperparathyroidism. Higher levels of circulating parathyroid hormone will lead to breakdown and weakening of bones, and eventually cause fractures. These derangements can cause calcium to build up in the walls of blood vessels and severely affect circulation over time.

Symptoms of mineral and bone disease 


The most common symptoms of bone disease are:

  • Bone pain
  • Fractures
  • Hyperparathyroidism


What to expect from bone disease treatment 


Your nephrologist will follow your kidney function and specific hormone and vitamin levels. Sometimes medications and supplements are needed and effective treatment is thought to prevent many of the complications including fractures and problems with circulation.

Any vitamins, herbal medications or changes to diet should be discussed with your nephrologist first.


Diet Guides

Go to Diet Guides

Mineral and Bone Disorder FAQs


Bone Disease Patient Resource Guide

Go to National Kidney Foundation

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